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Propofol is being increasingly used in anaesthesia practice because of its properties like smooth induction,rapid and clear headed recovery and absence of cumulative effects. But pain during its intravenous injection is still being tackled. In our mission to control this pain, we compared Inj. Lignocaine, which is normally used for this purpose, with other routinely used drug in anesthesia. The study compares Lignocaine with Metoclopramide,a prokinetic,and combination of both of these drugs to control pain of intravenous Propofol injection. The study helped us understand the inadequacies of the previous pain management and provide better pain relief to the patients.
The structural identifiability analyses of established and novel glucose-insulin models for the studies of diabetes was performed, to determine whether the models are globally structurally identifiable with the observations available. Structural identifiability analysis is an essential step in the modelling process and a key prerequisite to experimental design and parameter estimation. Analyses presented assuming observations of both glucose and insulin concentrations on two versions of the well-cited Minimal Model, the Original Minimal Model and Extended Minimal Model for the modelling of the responses to an Intravenous Glucose Tolerance Test; a Euglycemic Hyperinsulinemic Clamp model and two novel modified versions of the Minimal Model, a Closed-Loop Minimal Model and a Double-Pole in Closed-Loop Minimal Model, when the models describe a complete course of glucose-insulin dynamics during an Intravenous Glucose Tolerance Test.